Proteolytic Cleavage and Phosphorylation of a Tumor- associated ErbB4 Isoform Promote Ligand-independent Survival and Cancer Cell Growth□D
نویسندگان
چکیده
*Medicity Research Laboratory and Department of Medical Biochemistry and Molecular Biology, ‡Turku Postgraduate School of Biomedical Sciences, and §Department of Pathology, University of Turku, FIN-20520 Turku, Finland; Laboratory of Cancer Biology, Institute of Medical Technology, Tampere University and Tampere University Hospital, FIN-33101 Tampere, Finland; ¶Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143; and #Department of Oncology, Turku University Central Hospital, FIN-20520 Turku, Finland
منابع مشابه
Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.
The ErbB1 and ErbB2 receptors are oncogenes with therapeutic significance in human cancer, whereas the transforming potential of the related ErbB4 receptor has remained controversial. Here, we have addressed whether four alternatively spliced ErbB4 isoforms differ in regulating cellular responses relevant for tumor growth. We show that the two tumor necrosis factor-alpha converting enzyme (TACE...
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